Sorbitol dehydrogenase

Sulkowski, Matthew J. Taleroski, Kiara A. Tereska, Matthew N. Sorbitol dehydrogenase, the second enzyme in the polyol pathway, converts sorbitol to fructose. This process contributes to oxidative stress because depletion of the cofactor NAD+ leads to more glucose entering the polyol pathway. Chronic oxidative stress generated by the polyol pathway contributes to diabetic cataract and other diabetic complications.

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